How Long Does Advil Stay In Your System

Advil is a non-steroidal anti-inflammatory drug (NSAID), which is prescribed for fever, and mild to moderate pain, such as the pain of arthritis and menstrual pain. Being NSAID means that Advil is not derived from steroids. The main ingredient of Advil is ibuprofen, which is also contained in many brands. For example, Genpril, Motrin IB, Advil, Midol IB, Smart Sense Children’s Ibuprofen and Proprinal.

How does Advil work

Advil inhibits 3 types of enzymes, including: cyclooxygenase I (COX I), cyclooxygenase II (COX II), and thromboxane synthase. That’s how Advil decreases platelets aggregation, as well as the synthesis of the inflammatory mediators known as prostaglandins, resulting in relieving pain, inflammation, and reducing fever.

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How long does Advil stay in your system

After the last dose, Advil is likely to stay in your system for up to 24 hours. However, there are other factors that can significantly affect this duration. Those factors differ from a person to another, including:

  • age
  • body mass
  • whether you’re a mild or a chronic user of Advil
  • your metabolic rate of drugs. That determines the rate of Advil elimination from your system.

Will Advil show on a drug test?

No, Advil is not likely to show on drug tests. The reason is that none is interested in testing for the non-steroidal anti-inflammatory drugs, such as Advil. People are usually required to undergo a 5-panel drug tests, including cocaine, amphetamine, opioids, phencyclidine and THC.

How long is Advil detectable


Once Advil is ingested, research shows that it rises in blood, reaching a noticeable peak plasma concentration within 15-30 minutes. Other researches show Advil to reach its peak concertation in plasma within 47, 62, or 120 minutes after administration, depending on the dosage form you administered, whether it is a suspension, chewable tablets, or conventional tablets, respectively.

Within a 2-to-4-hours half-life, half the ingested dose of Advil is eliminated from your blood. Therefore, starting from 15 minutes, and up to 24 hours, Advil is detectable in your blood.

Urine, hair, saliva and fingernails

Advil is quickly eliminated from the system, which makes it not likely to be detected in your hair, saliva or fingernails. In terms of urine where Advil is mainly eliminated, up to 24 hours since the last dose, Advil is likely detectable.

What drug tests will show the presence of Advil

  • Blood analysis
  • Urinalysis, such as gas-liquid chromatography

How is Advil stored in the body

After Advil ingestion, around 80% of the ibuprofen contained is absorbed from the digestive tract. Afterwards, around 99% of the absorbed ibuprofen bounds to plasma proteins. More than 90% of the ibuprofen contained in Advil is excreted through urine. Neither hair, nor saliva nor fingernails are likely to store ibuprofen.


  1. PubChem. Ibuprofen.
  2. Evans JA., et al. The excretion of ibuprofen by the horse – a preliminary report. Br J Sports Med. 1976 Oct;10(3):124-7.
  3. Rabia Bushra, et al. An Overview of Clinical Pharmacology of Ibuprofen. Oman Med J. 2010 Jul; 25(3): 155–1661. doi: 10.5001/omj.2010.49.
How Long Does Advil Stay In Your System
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Daniel Miller
Daniel Miller

Hey there! I'm Daniel, a 35 years old Ph.D. in pharmacology and a member of THC Detox. My research into cannabis shows how cannabis affects health, including how cannabinoids can be used in the treatment of various diseases. I've got a long list of scientific and medical publications that show the positive effects of cannabis clearly.

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