How long does Subutex stay in your system?

How long does Subutex stay in your system? Can Subutex be detected through drug-testing? Which tests? When can Subutex no longer be detected?
Such questions are repeatedly asked. The importance of those questions comes from 2 factors, including: monitoring the duration Subutex is able to effectively work on the system, as well as the impact drug-testing results may have on social life, such as employment.

Subutex

Subutex is a narcotic drug indicated to treat the opioids addiction (dependence) that occurs in the individuals abusing and/or misusing narcotics, such as morphine, heroin, codeine, oxycodone and hydrocodone. Subutex is available as sublingual tablets, synthesized in 2 different dosage strengths, including: 2mg and 8mg. The active ingredient Subutex tablets contains is buprenorphine, which is combined with hydrochloride. [1]

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How does Subutex work?

Subutex substitutes for the opioids the patient is addicted to, as it can bind to the same receptors in the brain, including μ (mu) and k (kappa) receptors. What makes Subutex effective is that it slowly and partially binds to the receptors, decreasing the need to other opioids. The same time, it has milder side effects, compared to methadone. [2]

How long does Subutex stay in your system?

Subutex can appear in the plasma as early as 30 minutes to 3.5 hours after it has been administered. The half-life of buprenorphine ranges from 28 – 37 hours, which can be simply defined as the time the body takes to metabolize (clear out) 50% of Subutex. Therefore, Subutex is likely to stay in the system for around 56 – 74 hours after administration. [3]

How long is Subutex detectable in urine, hair, blood, saliva and fingernails?
Actually, Subutex can’t be detected in saliva or in fingernails. But, it can be detected in urine, blood and hair for up to 4 days after administration.
Will Subutex show on a drug test?

No and Yes. That entirely depends on the techniques used in drug testing. Subutex can’t be detected through the standard drug screen panels, which are commonly used. Only specific techniques can detect Subutex. Currently, these techniques are not so common.

Do drug tests work on Subutex?

As mentioned above, specific tests are required to detect Subutex; otherwise Subutex is not likely be detected, even if you undergo urine-or-blood-opioid testing. The reason is that Subutex’s metabolites differ from the metabolites common drug tests look for.

What drug tests will show the presence of Subutex in the system?

The two tests below can detect Subutex through the detection of buprenophrine, as follows:

  1. Gas chromatography/mass spectrometry (GC/MS)
    Through the gas-chromatography/mass-spectrometry test, buprenophrine can be detected in blood, urine and hair.
  2. Enzyme immunoassay

That test depends on detecting norbuprenorphine in the urine. Norbuprenorphine is the metabolite resulting from the main ingredient of Subutex (buprenophrine).
How is Subutex stored in different parts of the body: urine, hair, blood, saliva, fingernails?

After Subutex absorption, it is quickly distributed to different body parts through blood stream. Because of the long half-time of Subutex, it stays active in the body for a long time. Afterwards, buprenorphine is metabolized by glucuroconjungation and cytochrome P450 CYP3A4, resulting in the norbuprenorphine-metabolite, which is less active. Then, an amount of norbuprenorphine metabolite is excreted through stool; while a smaller amount is excreted through urine. [2]

References

1 U.S. Food and Drug Administration. Subutex (buprenorphine hydrochloride) and Suboxone tablets (buprenorphine hydrochloride and naloxone hydrochloride). U.S. Department of Health and Human Services. Page Last Updated: 10/23/2014
Available from:
https://www.fda.gov/Drugs/DrugSafety/PostmarketDrugSafetyInformationforPatientsandProviders/ucm191520.htm

2 Electronic Medicines Compendium. Subutex 0.4 mg sublingual tablets.
Available from: https://www.medicines.org.uk/emcmobile/medicine/26453#PRODUCTINFO

3 Christopher Welsh, et al. Buprenorphine. Buprenorphine A (Relatively) New Treatment For Opioid DependencePsychiatry (Edgmont). 2005 Dec; 2(12): 29–39. Published online 2005 Dec. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2994593/

How long does Subutex stay in your system?
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